Salvia miltiorrhiza Bunge (Danshen) · interaction review discussion

Reduction of Warfarin Metabolism

Quellenbefund mit unverändertem Untersuchungskontext. Klinischer Schweregrad: nicht bewertet.

Salvia miltiorrhiza Bunge (Danshen): Lo et al. (1992) studied the effect of Salvia miltiorrhiza Bunge on warfarin metabolism in rats. It was found that Salvia miltiorrhiza Bunge decreased the absorption rate, apparent volume of distribution and clearance half-life of warfarin, and increased the peak concentration and time to peak thereby enhancing the anticoagulant effect of warfarin.

Befund HOS-368742 · warfarin · HOS-085950 · Originalquelle ↗

Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update ↗

Copyright © 2021 Zhuang, Liu, Zhao, Sun, He, Wang, Jia, Lin, Chu and Xi. Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update. DOI: 10.3389/fphar.2021.751107 · CC BY 4.0

Quellen-Hash: b46c221ac01dd09600094fcfc243f39e7e1846720f413ea49157075cd642ed78

• Fan H. Y. Fu F. H. Yang M. Y. Xu H. Zhang A. H. Liu K. (2010). Antiplatelet and Antithrombotic Activities of Salvianolic Acid. A. Thromb. Res. 126, e17–e22. 10.1016/j.thromres.2010.04.006
• Li L. Cheng X. Wang J. J. (2016a). The Research Progress of TCM Injections with Warfarin Drug Interactions. Chin. J. Geriatr. Care 14, 59–61. 10.3969/j.issn.1672-4860.2016.03.029
• Xie H. J. Fu H. Y. Zhu C. F. Huang Z. Charles D. S. (2009). Effects of Danshen Injection (Salvia Miltiorrhiza) on Pharmacodynamics and Pharmacokinetics of Warfarin in Rats. Herald Med. 28, 36–39. 10.3870/yydb.2009.01.011
• Wang X. Cheung C. M. Lee W. Y. Or P. M. Yeung J. H. (2010a). Major Tanshinones of Danshen (Salvia Miltiorrhiza) Exhibit Different Modes of Inhibition on Human CYP1A2, CYP2C9, CYP2E1 and CYP3A4 Activities In Vitro . Phytomedicine 17, 868–875. 10.1016/j.phymed.2010.05.003
• Qiu F. Zhang R. Sun J. Jiye A. Hao H. Peng Y. (2008). Inhibitory Effects of Seven Components of Danshen Extract on Catalytic Activity of Cytochrome P450enzyme in Human Liver Microsomes. Drug Metab. Dispos. 36, 1308–1314. 10.1124/dmd.108.021030
• Wang Y. J. (2015). Different Effects of Four Ingredients of Danshen on the CYP3A4 and CYP2C9 Expressions. Shanghai: Shanghai Jiaotong University.
• Wang X. D. Li J. L. Su Q. B. Guan S. Chen J. Du J. (2009). Impact of the Haplotypes of the Human Pregnane X Receptor Gene on the Basal and St John’s Wort-Induced Activity of Cytochrome P450 3A4 Enzyme. Br. J. Clin. Pharmacol. 67, 255–261. 10.1111/j.1365-2125.2008.03344.x
• Wang X. Lee W. Y. Or P. M. Yeung J. H. (2010b). Pharmacokinetic Interaction Studies of Tanshinones with Tolbutamide, a Model CYP2C11 Probe Substrate, Using Liver Microsomes, Primary Hepatocytes and In Vivo in the Rat. Phytomedicine 17, 203–211. 10.1016/j.phymed.2009.07.013
• Wu W. W. Yeung J. H. (2010). Inhibition of Warfarin Hydroxylation by Major Tanshinones of Danshen in the Rat In Vitro and In Vivo . Phytomedicine 17, 219–226. 10.1016/j.phymed.2009.05.005
• Zhou X. Chan K. Yeung J. H. (2012). Herb-drug Interactions with Danshen (Salvia Miltiorrhiza): a Review on the Role of Cytochrome P450 Enzymes. Drug Metabol. Drug Interact. 27, 9–18. 10.1515/dmdi-2011-0038
• Lo A. C. Chan K. Yeung J. H. K. Woo K. S. (1992). The Effects of Danshen (Salvia Miltiorrhiza) on Pharmacokinetics and Pharmacodynamics of Warfarin in Rats. Eur. J. Drug Metab. Pharmacokinet. 17, 257–262. 10.1007/BF03190157
• Tan Y. Z. Wu A. C. Tan B. Y. Wu Y. H. Tang L. F. Li J. H. (2002). Study on the Interactions of Berberine Displace Other Drug from Their Plasma Proteins Binding Sites. Chin. Pharmacol. Bull. 18, 576–578.
• Liu J. Wang X. Cai Z. Lee F. S. (2008). Effect of Tanshinone IIA on the Noncovalent Interaction between Warfarin and Human Serum Albumin Studied by Electrospray Ionization Mass Spectrometry. J. Am. Soc. Mass. Spectrom. 19, 1568–1575. 10.1016/j.jasms.2008.06.005
• Guo L. Zheng D. R. (2009). The Influence of Compound Danshen Dropping Pill in Coronary Heart Disease on PT, APTT and FIB. Chin. Med. Herald 6, 87–88. 10.3969/j.issn.1673-7210.2009.18.050
• Wang Q. (2013). Studies on FXa Inhibitors of Herba Lycopi and Salvia Mitiorrhizae. Nanjing: Nanjing University of Chinese Medicine.