Carthamus tinctorius L. (Honghua) · interaction review discussion

Reduce Platelet Aggregation

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Carthamus tinctorius L. (Honghua): The dried flower of Carthamus tinctorius L has the functions of promoting blood circulation and menstruation, relieving pain by removing blood stasis, and modern pharmacological studies have shown that it has anticoagulation and antiplatelet aggregation effects (Liu et al., 2012; Xu and Dong, 2012). Studies by Zhao et al. (2009) have shown that Carthamus tinctorius L. extract had a significant inhibitory effect on ADP-induced platelet aggregation in rabbits. It can significantly inhibit platelet aggregation in vivo and in vitro, and has a certain inhibitory effect on the activation of the endogenous coagulation system. It may produce a synergistic anticoagulant effect with warfarin. Studies by Liu et al. (2000), Zang et al. (2007), and Zhang et al. (2013) showed that safflower yellow, the main active ingredient in Carthamus tinctorius L., can inhibit platelet adhesion, 5-hydroxytryptamine (5-HT) release and increase the concentration of free Ca2+ induced by platelet activating factor, significantly improve blood coagulation function, and has anti-thrombotic effects. Zhang et al. (2016) studies in rats showed that the combined use of Carthamus tinctorius L. and warfarin significantly prolonged PT value and bleeding time, but has no effect on the blood concentration of warfarin.

Befund HOS-368745 · warfarin · HOS-085950 · Originalquelle ↗

Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update ↗

Copyright © 2021 Zhuang, Liu, Zhao, Sun, He, Wang, Jia, Lin, Chu and Xi. Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update. DOI: 10.3389/fphar.2021.751107 · CC BY 4.0

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