Lycium barbarum L. (Gouqizi)

Reduction of Warfarin Metabolism

Quellenbefund mit unverändertem Untersuchungskontext. Klinischer Schweregrad: nicht bewertet.

Lycium barbarum L. (Gouqizi): The mature fruit of Lycium barbarum L., family Solanaceae has the effect of nourishing the liver and kidney, benefiting the essence and brightening the eyes, treating liver and kidney yin deficiency and premature aging. It has anti-aging, hypolipidemic, hypoglycemic and hematopoietic effects. In an in vitro study (Leung et al., 2008), noted that Lycium barbarum L. tea inhibited warfarin metabolism by weakly inhibiting CYP2C9 activity in human liver microsomes, suggesting that this interaction may be due to the effect of factors such as absorption, P-glycoprotein or the anticoagulant effect of the herb itself. It was also observed that it was possible that the metabolites of Lycium barbarum L. displaced warfarin from its plasma protein binding site, leading to an increase in INR. Cheng (2012) confirmed using a Caco-2 cell assay that Lycium barbarum polysaccharides (LBP) may increase the absorption of the drug when combined with P-glycoprotein substrate, resulting in a higher blood concentration and enhanced efficacy. The high concentration of LBP increased the absorption of the drug by inhibiting the efflux transport of P-glycoprotein and increased the blood concentration and enhanced the effect of warfarin. Studies (Rivera et al., 2012; Zhuang et al., 2020) reported an unexplained and significant increase in INR value along with symptoms of rhinorrhagia, skin petechiae and rectal bleeding in an American woman after taking Lycium barbarum L. juice. Guzmán et al. (2021) reported a 75-year-old female patient who had a mitral valve replacement 3 years ago and was taking oral warfarin postoperatively with an INR controlled within the target range (2.5–3.5). Recent consumption of Lycium barbarum L. tea (1-2 cups per day) to prevent neocoronavirus infection eventually led to an increase in INR due to warfarin overdose.

Befund HOS-368749 · warfarin · HOS-085950 · Originalquelle ↗

Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update ↗

Copyright © 2021 Zhuang, Liu, Zhao, Sun, He, Wang, Jia, Lin, Chu and Xi. Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update. DOI: 10.3389/fphar.2021.751107 · CC BY 4.0

Quellen-Hash: b46c221ac01dd09600094fcfc243f39e7e1846720f413ea49157075cd642ed78

• Leung H. Hung A. Hui A. C. Chan T. Y. (2008). Warfarin Overdose Due to the Possible Effects of Lycium Barbarum L. Food Chem. Toxicol. 46, 1860–1862. 10.1016/j.fct.2008.01.008
• Cheng R. H. (2012). Effects of Lycium Barbarum Polysaccharide on P-Glycoprotein. Changsha: Central South University.
• Rivera C. A. Ferro C. L. Bursua A. J. Gerber B. S. (2012). Probable Interaction between Lycium Barbarum (Goji) and Warfarin. Pharmacotherapy 32, 50–53. 10.1002/j.1875-9114.2012.01018.x
• Zhuang W. Sun G. Lin X. Chen B. Wu L. Jiang D. (2020). Medication with Caution: Analysis of Adverse Reactions Caused by a Combination of Chinese Medicine and Warfarin Sodium Tablets. J. Ethnopharmacol. 254, 112586. 10.1016/j.jep.2020.112586
• Guzmán C. E. Guzmán-Moreno C. G. Assad-Morell J. L. Carrizales-Sepúlveda E. F. (2021). Flecainide Toxicity Associated with the Use of Goji Berries: a Case Report. Eur. Heart J. Case Rep. 5, 1–6. 10.1093/ehjcr/ytab204