Curcuma longa L. (Jianghuang) · interaction review discussion

Reduction of Warfarin Metabolism

Quellenbefund mit unverändertem Untersuchungskontext. Klinischer Schweregrad: nicht bewertet.

Curcuma longa L. (Jianghuang): Jianghuang is the dried rhizome of Curcuma longa L., family Zingiberaceae. It has the effect of blood circulation activity and pain relief. It has modern pharmacological effects such as antihypertensive, antibacterial, antiviral, hepatoprotective, antioxidant, hypolipidemic and antitumor. Curcuma longa L. promotes the synthesis of prostaglandin PGI2, reduces the production of TXA2, and interferes with the production of cAMP or Ca2+ in platelets. Xia Q et al. found that Curcuma longa L. had a strong inhibitory effect on the CYP3A isoform of the CYP450 enzyme system (Xia et al., 2012). Therefore, Curcuma longa L. in combination with warfarin may enhance the anticoagulant effect of warfarin and lead to bleeding; thus, INR values should be monitored during clinical treatment.

Befund HOS-368754 · warfarin · HOS-085950 · Originalquelle ↗

Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update ↗

Copyright © 2021 Zhuang, Liu, Zhao, Sun, He, Wang, Jia, Lin, Chu and Xi. Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update. DOI: 10.3389/fphar.2021.751107 · CC BY 4.0

Quellen-Hash: b46c221ac01dd09600094fcfc243f39e7e1846720f413ea49157075cd642ed78

• Xia Q. Wang X. Xu D. J. Chen X. H. Chen F. H. (2012). Inhibition of Platelet Aggregation by Curdione from Curcuma Wenyujin Essential Oil. Thromb. Res. 130, 409–414. 10.1016/j.thromres.2012.04.005