Angelica sinensis (Oliv) Diels. (Danggui) · interaction review discussion

Plants Containing Coumarin-like Ingredients Similar to Warfarin, Producing a Synergistic Effect

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Angelica sinensis (Oliv) Diels. (Danggui): The root of Angelica sinensis (Oliv) Diels. in the family Umbelliferae has pharmacological effects which include increasing coronary flow, reducing myocardial oxygen consumption, anti-arrhythmia, anti-atherosclerosis, inhibiting platelet aggregation, improving microcirculation, and improving immunity in the body. In 1995 Lo et al. (1995) showed using chemical analysis that Angelica sinensis contains coumarin-like active ingredients similar to warfarin such as parsley oil methyl ether and psoralen. These ingredients can inhibit the formation of thromboxane and platelet aggregation (Liu et al., 1995), and have a synergistic effect when combined with warfarin; in animal experiments, it was concluded that angelica had no effect on PT and pharmacokinetic parameters in warfarin single-dose experiments (p > 0.05). However, in warfarin steady-state experiments, angelica prolonged PT in rabbits, but had no effect on warfarin blood concentrations. Another reason may be that warfarin is able to displace angelica from its binding to plasma proteins, thereby increasing the blood concentration of angelica, which in excess produces anticoagulant effects due to the presence of coumarin-like components. Ye Z.W. reported (Ye et al., 2014) that ferulic acid in angelica administered in vivo or in vitro inhibits PAF, inhibits platelet aggregation reaction and enhances the anticoagulant effect of warfarin.

Befund HOS-368766 · warfarin · HOS-085950 · Originalquelle ↗

Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update ↗

Copyright © 2021 Zhuang, Liu, Zhao, Sun, He, Wang, Jia, Lin, Chu and Xi. Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update. DOI: 10.3389/fphar.2021.751107 · CC BY 4.0

Quellen-Hash: b46c221ac01dd09600094fcfc243f39e7e1846720f413ea49157075cd642ed78

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