Panax quinquefolius L. (Xiyangshen) · interaction review discussion

Induction of Cytochrome P450 Enzyme Activity and Reduction of Warfarin Anticoagulation

Quellenbefund mit unverändertem Untersuchungskontext. Klinischer Schweregrad: nicht bewertet.

Panax ginseng C.A.Mey. (Renshen) and Panax quinquefolius L. (Xiyangshen): The dried roots of Panax ginseng C.A.Mey. of the family Pentacostaceae have the effects of invigorating qi, promoting body fluid, soothing the nerves, and nourishing the mind. The modern pharmacological effects include anti-shock, increasing the amplitude of heartbeat and heart rate, anti-fatigue, promoting hematopoiesis, regulating cholesterol metabolism, enhancing the immune function of the body, and lowering blood sugar. Xiyangshen is the root of Panax quinquefolius L., a plant in the Araliaceae family, with the effects of tonifying qi and nourishing yin, clearing heat and generating fluid, improving immunity, inhibiting platelet coagulation, promoting blood circulation, and preventing arterial atherosclerosis. You et al. (2015) showed that these two herbs combined with warfarin decreased the INR in patients. Panax ginseng C.A.Mey. and Panax quinquefolius L. contain a variety of ginsenosides, of which ginsenoside F1 may induce the gene expression of CYP3A4 and enhance its enzymatic activity by activating the progesterone receptor in a concentration-dependent manner. However, it has also been shown (Malati et al., 2012) that ginsenosides Rg3, Rh2, and C-K inhibit the activities of CYP2C9, CYP3A4, and CYP2C19, while Rb1 and C-K moderately inhibit the activity of CYP1A2, and low doses of ginseng do not alter the activities of CYP3A4 and P-glycoprotein (Janetzky and Morreale, 1997; Hao et al., 2008). There are mixed findings in the literature regarding the effects of ginseng on CYP450 enzymes, and the mechanism by which it attenuates the anticoagulant effect of warfarin remains to be further clarified.

Befund HOS-368772 · warfarin · HOS-085950 · Originalquelle ↗

Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update ↗

Copyright © 2021 Zhuang, Liu, Zhao, Sun, He, Wang, Jia, Lin, Chu and Xi. Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update. DOI: 10.3389/fphar.2021.751107 · CC BY 4.0

Quellen-Hash: b46c221ac01dd09600094fcfc243f39e7e1846720f413ea49157075cd642ed78

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