Ginkgo biloba extract (GBE)

Reduction of Warfarin Metabolism

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Ginkgo biloba extract (GBE): Ginkgo is a genus of Ginkgo biloba L. in the family Ginkgoaceae, also known as white fruit tree, gongsun tree, and duck palm tree, whose medicinal parts are mainly the leaves and fruits. Ginkgo has the functions of invigorating blood circulation, and removing blood stasis. Modern pharmacological studies have shown that ginkgo has hepatoprotective, antitumor, antiradiation, and renal protective effects, as well as antioxidant, pro-intellectual, anti-anxiety, sedative, lipid regulating and reducing ischemia-reperfusion injury effects (Han et al., 2007; Shi, 2008). Tan et al. (2011) found that Ginkgo biloba extract (GBE) could block the production of platelet-derived growth factors through the inhibition of tyrosine kinase, thereby inhibiting thrombin-induced platelet activation and aggregation, with no or minimal effect on coagulation. In vitro studies have shown that GBE affects the enzymatic activity of CYP2C9 in vivo, thereby affecting S-warfarin 7-hydroxylation. However, in vivo studies have shown that GBE has no effect on the metabolism of the CYP2C9 substrates diclofenac and toluenesulfonylurea, and that neither GBE nor ginkgolide B affects the coagulation process, but that ginkgolide attenuates the anticoagulant effect of warfarin by inducing S-warfarin hydroxylase. Some experiments in rats have shown that GBE induces CYPs, but enzyme activity is quickly restored after discontinuation of dosing. GBE had no significant effect on single-dose warfarin pharmacodynamics, no effect on PT and APTT, and no significant change in apparent volume of distribution, but increased peak warfarin concentration, AUC, half-life, and decreased its clearance (Zhou and Zeng, 2011).

Befund HOS-368776 · warfarin · HOS-085950 · Originalquelle ↗

Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update ↗

Copyright © 2021 Zhuang, Liu, Zhao, Sun, He, Wang, Jia, Lin, Chu and Xi. Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update. DOI: 10.3389/fphar.2021.751107 · CC BY 4.0

Quellen-Hash: b46c221ac01dd09600094fcfc243f39e7e1846720f413ea49157075cd642ed78

• Han S. Z. Ping F. Li X. (2007). Effect of the Ginkgo Leaves Extract on Platelet Activation in the Patients with Chronic Cor Pulmonale during Acute Period. Hebei Med. J. 29, 49. 10.3969/j.issn.1002-7386.2007.01.022
• Shi J. M. (2008). Advances in Pharmacological Research on Ginkgo Biloba. Int. Med. Health Guid. News 14, 122.
• Tan P. Hao Y. Ding S. J. Peng K. R. Liu Y. (2011). Mechanism of Platelet Anti-aggregation with Ginkgo Biloba Extract. Chin. J. Neuromed. 10, 260–263. 10.3760/cma.j.issn.1671-8925.2011.03.011
• Zhou Y. L. Zeng R. (2011). Effects of Ginkgo Biloba Extract on Anticoagulation and Blood Drug Level of Warfarin in Healthy Volunteers. Chin. J. Chin. Mater. Med. 36, 2290–2293. 10.4268/cjcmm20111628