Fufang Danshen Dripping Pills · interaction review discussion

Reduction of Warfarin Metabolism

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Fufang Danshen Dripping Pills: Fufang Danshen Dripping Pills have the effect of activating blood circulation, resolving blood stasis, regulating qi and relieving pain. Fufang Danshen Dripping Pills consist of Salvia miltiorrhiza Bunge, Panax notoginseng, and borneol. Yi et al. (2013) found that Fufang Danshen Dripping Pills (Salvia miltiorrhiza Bunge, Panax notoginseng, and borneol, 27 mg/pill, Tianshili Pharmaceutical Group Co., Ltd.) could alter the pharmacokinetic parameters of warfarin. Total Panax notoginseng saponin can reduce the metabolic rate of warfarin and enhance its anticoagulant effect by inhibiting its hydroxylation in rats. Yi et al. (2013) found that Fufang Danshen Dripping Pills alone for 4 weeks had a significant effect on coagulation. A significant increase in PT values was observed following the combination of Fufang Danshen Dripping Pills and warfarin, thus it was hypothesized that Fufang Danshen Dripping Pills and warfarin have a synergistic effect on anticoagulation. A clinical study (Guo and Zheng, 2009) found that the Cmax, AUC0∼144, AUC0∼∞, t1/2, PT, and APTT of warfarin were increased in healthy volunteers who were co-administered Fufang Danshen Dripping Pills, suggesting that Fufang Danshen Dripping Pills can affect the metabolism of warfarin and enhance its anticoagulant effect. However, animal experiments have also shown (Chu et al., 2011) that there were no significant changes in warfarin pharmacodynamics and pharmacokinetics when Fufang Danshen Dripping Pills were administered with warfarin, suggesting that regular doses of Fufang Danshen Dripping Pills may have no effect on warfarin pharmacodynamics and pharmacokinetics in humans. Due to inconsistent results between animal experiments and clinical applications, further research is needed.

Befund HOS-368780 · warfarin · HOS-085950 · Originalquelle ↗

Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update ↗

Copyright © 2021 Zhuang, Liu, Zhao, Sun, He, Wang, Jia, Lin, Chu and Xi. Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update. DOI: 10.3389/fphar.2021.751107 · CC BY 4.0

Quellen-Hash: b46c221ac01dd09600094fcfc243f39e7e1846720f413ea49157075cd642ed78

• Yi D. Luo X. B. Lu X. H. Luo S. P. Zhou Y. L. (2013). The Effects of Compound Danshen Dripping Pills on the Pharmacodynamics and Pharmacokinetics of Warfarin in Humans. Chin. J. Pharmacovigilance 10, 65–67. 10.3969/j.issn.1672-8629.2013.02.001
• Guo L. Zheng D. R. (2009). The Influence of Compound Danshen Dropping Pill in Coronary Heart Disease on PT, APTT and FIB. Chin. Med. Herald 6, 87–88. 10.3969/j.issn.1673-7210.2009.18.050
• Chu Y. Zhang L. Wang X. Y. Guo J. H. Guo Z. X. Ma X. H. (2011). The Effect of Compound Danshen Dripping Pills, a Chinese Herb Medicine, on the Pharmacokinetics and Pharmacodynamics of Warfarin in Rats. J. Ethnopharmacol. 137, 1457–1461. 10.1016/j.jep.2011.08.035