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Goldenseal is a plant native to the northeastern United States and southeastern Canada. It has a bright yellow rhizome (underground stem). Wild goldenseal has been overharvested and is available in limited amounts. The plant is grown commercially but is expensive to cultivate. Historically, Native Americans used goldenseal to treat a variety of conditions, such as digestive disorders, wounds, skin and eye conditions, and cancer. Currently, goldenseal is promoted as a dietary supplement for the common cold and other upper respiratory tract infections, hay fever, diarrhea, constipation, and other conditions.

There is not enough evidence to determine whether goldenseal is useful for any health conditions. More research would be needed before any conclusions can be reached.

No rigorous studies have been done to evaluate the effects of goldenseal on health conditions in people. Berberine, a substance found in goldenseal, has been studied for its effects on blood sugar, blood cholesterol levels, body weight, and other health-related outcomes. However, when people take goldenseal orally (by mouth), very little berberine may be absorbed by the body, so study results on berberine may not apply to goldenseal.

In small research studies, goldenseal has been administered at doses of about 3 g per day for short periods of time without serious harmful effects. The safety of taking goldenseal for longer periods is uncertain. Some commercial goldenseal products have been found to contain other herbs or ingredients not listed on the label in addition to or instead of goldenseal. Goldenseal may change the way your body processes many medications. For example, a study funded by the National Center for Complementary and Integrative Health (NCCIH) found that levels of metformin—the most commonly prescribed diabetes medicine—decreased about 25 percent in healthy adults who were given goldenseal extract plus metformin. This drop was enough to potentially hinder glucose control in people with type 2 diabetes taking metformin. If you take any type of medicine, talk with your health care provider before using goldenseal or other herbal products; some herbs and medicines interact in harmful ways. Women who are pregnant or breastfeeding should not use goldenseal, and it should not be given to infants. The berberine constituent of goldenseal can be harmful to newborns.

Zusätzliche Literaturverweise aus der lokalen Suche. Titel und Metadaten wurden gefunden; Abstracts und Aussagen wurden damit noch nicht bewertet.

• Goldenseal (Hydrastis canadensis L.) and its active constituents: A critical review of their efficacy and toxicological issues. · PMID 32683037
• Supplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivo. · PMID 17495878
• Effect of goldenseal (Hydrastis canadensis) and kava kava (Piper methysticum) supplementation on digoxin pharmacokinetics in humans. · PMID 17079360

NCCIH: Goldenseal. Abgerufen: 27.10.2026. Öffentliche Originaltexte; Bildrechte separat.

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