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Kyprolis
Eintrag öffnenKyprolis · 4.1 Therapeutic indications · 1
Eintrag öffnenKyprolis · 4.3 Contraindications · 1
Eintrag öffnenKyprolis · 4.3 · As Kyprolis is administered in combination with other medicinal products, refer to their summaries of product
Eintrag öffnenKyprolis · 4.3 · • Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. • Women who are
Eintrag öffnenKyprolis · 4.4 Special warnings and precautions for use · 1
Eintrag öffnenKyprolis · 4.5 Interaction with other medicinal products and other forms of interaction · 1
Eintrag öffnenKyprolis · 4.5 · Carfilzomib does not inhibit CYP1A2, 2B6, 2C8, 2C9, 2C19 and 2D6 in vitro and is therefore not expected to inf
Eintrag öffnenKyprolis · 4.5 · Carfilzomib is a P-glycoprotein (P-gp) but not a BCRP substrate. However, given that Kyprolis is administrated
Eintrag öffnenKyprolis · 4.5 · Carfilzomib is primarily metabolised via peptidase and epoxide hydrolase activities, and as a result, the phar
Eintrag öffnenKyprolis · 4.5 · In vitro studies indicated that carfilzomib did not induce human CYP3A4 in cultured human hepatocytes. A clini
Eintrag öffnenKyprolis · 4.5 · In vitro, carfilzomib inhibits OATP1B1 with an IC50 = 2.01 µM whereas it is unknown whether carfilzomib may or
Eintrag öffnenKyprolis · 4.6 Fertility, pregnancy and lactation · 1
Eintrag öffnenKyprolis · 4.8 Undesirable effects · 1
Eintrag öffnenKyprolis · 4.8 · 15 Following initial doses of carfilzomib at 20 mg/m2, the dose was increased to 27 mg/m2 in study PX-171-009
Eintrag öffnenKyprolis · 4.8 · 16 MedDRA system Very common Common Uncommon Rare organ class (≥ 1/10) (≥ 1/100 to < 1/10) (≥ 1/1 000 to < 1/1
Eintrag öffnenKyprolis · 4.8 · 17 MedDRA system Very common Common Uncommon Rare organ class (≥ 1/10) (≥ 1/100 to < 1/10) (≥ 1/1 000 to < 1/1
Eintrag öffnenKyprolis · 4.8 · 18 cyclical thrombocytopenia with platelet nadirs occurring on day 8 or 15 of each 28-day cycle and usually as
Eintrag öffnenKyprolis · 4.8 · 19 Hepatitis B reactivation
Eintrag öffnenKyprolis · 4.8 · Adverse reactions are presented below by system organ class and frequency category (see table 6). Frequency ca
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