Glycyrrhiza glabra L. (Gancao) · interaction review discussion

Reduction of Warfarin Metabolism

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Glycyrrhiza glabra L. (Gancao): Glycyrrhiza glabra L. is the dried root and rhizome of Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L., a genus of licorice in the family Fabaceae. It has the effects of benefiting the qi and tonifying the middle, moistening the lung and relieving cough, clearing heat and detoxifying, relieving pain and harmonizing medicinal properties. It has modern pharmacological effects such as adrenocorticotropic hormone-like effects, anti-platelet aggregation, anti-peptic ulcer, antipyretic, sedative, and immune enhancing. Qiao et al. (Qiao et al., 2014) analyzed the interaction of more than 40 chemical components in Glycyrrhiza glabra L. with cytochrome P450 enzymes and showed that the flavonoids, terpenoids and coumarins in Glycyrrhiza glabra L. had different degrees of inhibitory effects on the activities of CYP1A2, 2C9, 2C19, 2D6 and 3A4/5, which resulted in slower warfarin metabolism, longer half-life and higher INR. Flavonoids can inhibit platelet function through multiple links (Xiang et al., 2008), mainly including blocking platelet activating factor (PAF) binding to platelet receptors, inhibiting the release of platelet endogenous substances, inhibiting the increase in intra-platelet Ca2+ and balancing the intra-platelet thromboxane B2-6-keto-prostaglandin (TXB2-6-keto-PGFla) system, which synergistically anticoagulated with warfarin.

Befund HOS-368751 · warfarin · HOS-085950 · Originalquelle ↗

Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update ↗

Copyright © 2021 Zhuang, Liu, Zhao, Sun, He, Wang, Jia, Lin, Chu and Xi. Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update. DOI: 10.3389/fphar.2021.751107 · CC BY 4.0

Quellen-Hash: b46c221ac01dd09600094fcfc243f39e7e1846720f413ea49157075cd642ed78

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