Glycyrrhiza glabra L. (Gancao)

Reduction of Warfarin Metabolism

Quellenbefund mit unverändertem Untersuchungskontext. Klinischer Schweregrad: nicht bewertet.

Glycyrrhiza glabra L. (Gancao): Glycyrrhiza glabra L. is the dried root and rhizome of Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L., a genus of licorice in the family Fabaceae. It has the effects of benefiting the qi and tonifying the middle, moistening the lung and relieving cough, clearing heat and detoxifying, relieving pain and harmonizing medicinal properties. It has modern pharmacological effects such as adrenocorticotropic hormone-like effects, anti-platelet aggregation, anti-peptic ulcer, antipyretic, sedative, and immune enhancing. Qiao et al. (Qiao et al., 2014) analyzed the interaction of more than 40 chemical components in Glycyrrhiza glabra L. with cytochrome P450 enzymes and showed that the flavonoids, terpenoids and coumarins in Glycyrrhiza glabra L. had different degrees of inhibitory effects on the activities of CYP1A2, 2C9, 2C19, 2D6 and 3A4/5, which resulted in slower warfarin metabolism, longer half-life and higher INR. Flavonoids can inhibit platelet function through multiple links (Xiang et al., 2008), mainly including blocking platelet activating factor (PAF) binding to platelet receptors, inhibiting the release of platelet endogenous substances, inhibiting the increase in intra-platelet Ca2+ and balancing the intra-platelet thromboxane B2-6-keto-prostaglandin (TXB2-6-keto-PGFla) system, which synergistically anticoagulated with warfarin.

Befund HOS-368751 · warfarin · HOS-085950 · Originalquelle ↗

Plants Containing Coumarin-like Ingredients Similar to Warfarin, Producing a Synergistic Effect

Quellenbefund mit unverändertem Untersuchungskontext. Klinischer Schweregrad: nicht bewertet.

Glycyrrhiza glabra L. (Gancao): The coumarin derivatives in Glycyrrhiza glabra L. (Chen et al., 2018) may show antiplatelet activity by increasing intra-platelet cAMP. However, animal tests have also shown that Glycyrrhiza glabra L. activates pregnane X receptors (PXR) and increases the clearance of warfarin, thereby reducing its anticoagulant effect, so the mechanism of interaction between Glycyrrhiza glabra L. and warfarin requires further investigation.

Befund HOS-368752 · warfarin · HOS-085950 · Originalquelle ↗

Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update ↗

Copyright © 2021 Zhuang, Liu, Zhao, Sun, He, Wang, Jia, Lin, Chu and Xi. Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update. DOI: 10.3389/fphar.2021.751107 · CC BY 4.0

Quellen-Hash: b46c221ac01dd09600094fcfc243f39e7e1846720f413ea49157075cd642ed78

• Qiao X. Ji S. Yu S. W. Lin X. H. Jin H. W. Duan Y. K. (2014). Identification of Key Licorice Constituents Which Interact with Cytochrome P450: Evaluation by LC/Ms/Ms Cocktail Assay and Metabilic Profiling. AAPS J. 16, 101–113. 10.1208/s12248-013-9544-9
• Xiang Y. Z. Shang H. C. Zhang B. L. (2008). Advances in Studies on Chinese Materia Medica with Antiplatelet Function. Chin. Tradit. Herbal Drugs 39, 290–294. 10.3321/j.issn:0253-2670.2008.02.04910.1002/chin.200810266
• Chen Z. Zhao M. Gao N. (2018). INR Elevation Caused by the Interaction of Strengthening and Regulating Qi and Warfarin in 1 Case. Chin. J. Mod. Appl. Pharm. 35, 434–435. 10.13748/j.cnki.issn1007-7693.2018.03.029